GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2129782 | 1 | rs59484067 | chr8:89409343 | MMP16 | chr8:89049462-89339717:- | 0.34 | 5.25 | 2.25E-7 | Electrodermal activity |
| THCA | cis | rs2129782 | 1 | rs59495340 | chr8:89452311 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs3771570 | 1 | rs59496049 | chr2:242260756 | SEPT2 | chr2:242254723-242293439:+ | -0.28 | -4.71 | 3.32E-6 | Prostate cancer |
| THCA | cis | rs4950322 | 1 | rs59498179 | chr1:146872147 | FMO5 | chr1:146655885-146697230:- | 0.24 | 3.87 | 0.000125 | Protein quantitative trait loci |
| THCA | cis | rs9346353 | 1 | rs59510607 | chr6:70482983 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.55 | 0.000425 | Sleep duration |
| THCA | cis | rs7714584 | 1 | rs59531858 | chr5:150247063 | LOC134466 | chr5:150310000-150326146:- | 0.44 | 5.85 | 9.03E-9 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs59531858 | chr5:150247063 | ZNF300 | chr5:150273964-150284391:- | 0.16 | 3.39 | 0.000744 | Crohn's disease |
| THCA | cis | rs3771570 | 1 | rs59536819 | chr2:242272388 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.13 | 4.26E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs59536819 | chr2:242272388 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.17 | 3.59E-5 | Prostate cancer |
| THCA | cis | rs12304921 | 1 | rs59546367 | chr12:51345373 | SLC11A2 | chr12:51373319-51422058:- | -0.23 | -4.64 | 4.46E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs59546367 | chr12:51345373 | TFCP2 | chr12:51488608-51566917:- | -0.19 | -4.07 | 5.58E-5 | Type 2 diabetes |
| THCA | cis | rs12435908 | 1 | rs59561356 | chr14:66020022 | LOC645431 | chr14:65877313-65879335:- | -0.58 | -7.31 | 1.13E-12 | Ischemic stroke |
| THCA | cis | rs2129782 | 1 | rs59580800 | chr8:89437373 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs3796352 | 1 | rs59583591 | chr3:53119581 | RFT1 | chr3:53122503-53164470:- | 0.59 | 7.31 | 1.17E-12 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs6988636 | 1 | rs59601467 | chr8:124193488 | FAM83A | chr8:124191287-124222317:+ | -0.3 | -4.02 | 6.9E-5 | Urinary uromodulin levels |